ME 141C Course Information

Instructor:	C. D. Meinhart Office: 2323 Eng. II Ph: 893-4563 Email: Meinhart@engr.ucsb.edu Web: www.me.ucsb.edu/meinhart
Lecture Time:	Tues/Thurs. 11:00 – 12:15 pm ESB 1003
Prerequisites:	ME 152A/B (or equivalent), ME 141A (can be waived by instructor)
TA:	Marin Sigurdson marin@engr.ucsb.edu TA Office Hours: Monday 9:15 - 11:00 am & Friday 1:15 - 2:45 pm in the CAD Lab

Course Description

This class focuses on the physics of fluid mechanics that occurs at the micro / nanoscale, and is applicable to MEMS and BioMEMS. Particular emphasis is place on using finite element software (Femlab) to simulate multi-physics problems associated with microfluidics, and can be extended to a wide variety of engineering problems.

Topics

I. Introduction / Background
II. Microscale Fluid Mechanics Theory
III. Electrokinetic Phenomena
IV. Experimental Flow Characterization
V. Microfluidics for Life Sciences

Grading

Homework (4 - 5)	50%
Research Report	50%

Recommended Texts (on reserve at the library)

Microfluidics for Biotechnology (2005), Jean Berthier & Pascal Silberzan, Artech House, Boston, ISBN 1580539610.

Fundamentals and Applications of Microfluidics, (2002), Nam-Trung Nguyen & Steven T.
Wereley, Artech House, Boston.

AC Electrokinetic: Colloids and Nanoparticles (Microtechnologies and Microsystems) by Hywel Morgan, Nicolas G. Green_ ISBN 0 86380 255 9

Fundamentals of Microfabrication, Marc Madou, CRC Press, 1997.

DNA Simplified II: The Illustrated Hitchhiker’s Guide to DNA, Daniel H. Farkas, AACC Press, 1999.

Analysis of Transport Phenomena, Bill Dean Oxford University Press, 1998.

Chemiophisiohydrodynamics, Robert Probstein.

Nano: The Emerging Science of Nanotechnology, Ed Regis, Little, Brown, & Co. 1995.

Outline

I. Introduction / Background (Notes)

Overview of MEMS Applications
MEMS Market Trends
Scaling Laws

II. Microscale Fluid Mechanics Theory

Governing Equations
Elementary Solutions
Surface dominated physics
Electrokinetic & electrothermal effects
Surface reaction kinetics

III. Electrokinetic Phenomena

Maxwell’s Equations & Electrostatics
Electrophoresis
Electro-osmosis
Dielectrophoresis (DEP)
Electrothermal Flow
Electrokinetic Instabilities

IV. Experimental Flow Characterization

Introduction to micron-resolution Particle Image Velocimetry
Slip flow boundary conditions
Analysis of AC Electrokinetic phenomena
Mixing in microchannels

V. Microfluidics for Life Sciences

Microarray Technology for high throughput screening
Sandwich Immunoassay Devices
DNA Sequencing and Analysis Devices
Micro Total Analysis Systems
Proteomics
Single Molecule Detection

Academic Goals

1. Understand physics associated with microscale fluid mechanics

a. Electrokinetics & electrothermal effects
b. Surface-dominated effects
c. Chemical kinetics
d. Particle dynamics

2. Gain knowledge in the field of BioMEMS

a. Optical techniques for molecular diagnostics
b. Single molecule detection
c. Microfluidics & biotechnology

3. Understand and apply computational tools to solve advanced problems

a. Femlab (finite element software, runs with Matlab)
b. Research Tool
c. Design Tool

4. Gain experience in conducting and presenting research projects

a. Research Project
b. Homework