The Valentine Lab at the University of California, Santa Barbara
Molecular & Cellular Biomechanics, Biomaterials, Bioadhesion

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    1. Benjamin J. Lopez and Megan T. Valentine. "Mechanical effects of EB1 on microtubules depend on GTP hydrolysis state and presence of paclitaxel" Cytoskeleton, In Press.


    2. Dezhi Yu, Nichole E. LaPointe, Elmer Guzman, Veronica Pessino, Leslie Wilson, Stuart C. Feinstein, and Megan T. Valentine. "Tau Proteins Harboring Neurodegeneration-linked Mutations Impair Kinesin Translocation in vitro" Journal of Alzheimer's Disease 39 301-314 (2014). [LINK]


    3. Yali Yang and Megan T. Valentine. “Determining the structure-mechanics relationships of dense microtubule networks with microscopy and microrheology,” Methods in Cell Biology 115 75-96 (2013). [LINK].


    4. Dezhi Yu, Veronica Pessino, Steve Kuei, and Megan T. Valentine. “Mechanical and functional properties of epothilone-stabilized microtubules,” Cytoskeleton 70(2) 74-84 (2013). [LINK].


    5. Bugra Kaytanli and Megan T. Valentine. “Evolute-based Hough transform method for characterization of ellipsoids,” Journal of Microscopy 249(3) 159-164 (2013). [LINK].


    6. Yali Yang, Mo Bai, William S. Klug, Alex J. Levine and Megan T. Valentine. “Microrheology of highly crosslinked microtubule networks is dominated by force-induced crosslinker unbinding,” Soft Matter 9 383-393 (2013). [LINK]


    7. David Valdman, Benjamin J. Lopez, Megan T. Valentine, and Paul J. Atzberger. “Force spectroscopy of complex biopolymers with heterogeneous elasticity,” Soft Matter 9 772-778 (2013). [LINK]


    8. Jun Lin and Megan T. Valentine. “High-force NdFeB-based magnetic tweezers device optimized for microrheology experiments,” Review of Scientific Instruments 83 053905 (2012). [LINK]


    9. Jun Lin and Megan T. Valentine. “Ring-shaped NdFeB-based magnetic tweezers enables oscillatory microrheology measurements,” Applied Physics Letters 100 201902 (2012). [LINK]


    10. David Valdman, Paul J. Atzberger, Dezhi Yu, Steve Kuei and Megan T. Valentine. “Spectral Analysis Methods for the Robust Measurement of the Flexural Rigidity of Biopolymers,” Biophysical Journal 102(5) 1144-1153 (2012). [LINK]


    11. Yali Yang*, Jun Lin*, Bugra Kaytanli, Omar Saleh and Megan T. Valentine. “Direct correlation between creep compliance and deformation in entangled and sparsely crosslinked microtubule networks,” Soft Matter 8 1776-1784 (2012). [LINK]


    12. Yali Yang*, Jun Lin*, Ryan Meschewski, Erin Watson, and Megan T. Valentine. “Portable magnetic tweezers device enables visualization of the three-dimensional microscale deformation of soft biological materials,” BioTechniques 51 29-34 (2011). [PDF]


    13. Megan T. Valentine and Steven M. Block. “Force and premature binding of ADP can regulate the processivity of individual Eg5 dimers,” Biophysical Journal 97 1671-7 (2009). [PUBMED]


    14. Michael T. Woodside and Megan T. Valentine . (2009) “Single-molecule manipulation using optical traps,” in Handbook of Single-Molecule Biophysics, eds. Peter Hinterdorfer and Antoine Van Oijen. New York, NY: Springer.


    15. Megan T. Valentine* , Nicholas R. Guydosh*, Braulio Gutiérrez-Medina*, Adrian N. Fehr*, Johan O. Andreasson*, and Steven M. Block. “Precision steering of an optical trap by electro-optic deflection,” Optics Letters 33 599-601 (2008). [PUBMED]


    16. Megan T. Valentine and Susan P. Gilbert. “To Step or Not to Step? How Biochemistry and Mechanics Influence Processivity in Kinesin and Eg5,” Current Opinion in Cell Biology 19 75-81 (2007). [PUBMED]


    17. Polly M. Fordyce*, Megan T. Valentine * and Steven M. Block. 2007. “Advances in surface-based assays for single molecules,” in Single-Molecule Techniques: A Laboratory Manual, eds. Paul Selvin and Taekjip Ha. Woodbury, NY: Cold Spring Harbor Laboratory Press.


    18. Megan T. Valentine , Polly M. Fordyce, and Steven M. Block. “Eg5 steps it up!,” Cell Division 1 31 (2006). [PUBMED]


    19. Megan T. Valentine *, Polly M. Fordyce*, Troy C. Krzysiak, Susan P. Gilbert, Steven M. Block. “Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro,” Nature Cell Biology 8 470 (2006). [PUBMED]


    20. M.T. Valentine , Z.E. Perlman, T.J. Mitchison, and D.A. Weitz. “Mechanical properties of Xenopus egg cytoplasmic extracts,” Biophysical Journal 88 680 (2005). [PUBMED]


    21. M.L. Gardel, M.T. Valentine , and D.A. Weitz. (2005) “Microrheology” in Microscale Diagnostic Techniques ed. K. Breuer. New York: Springer-Verlag. [PDF]


    22. M.T. Valentine , Z.E. Perlman, M.L. Gardel, J.H. Shin, P. Matsudaira, T.J. Mitchison, and D.A. Weitz. “Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials,” Biophysical Journal 86 4004-14 (2004). [PUBMED]


    23. I.Y. Wong, M.L. Gardel, David R. Reichman, Eric R. Weeks, M.T. Valentine , A.R. Bausch, D.A. Weitz. “Anomalous diffusion probes microstructure dynamics of entangled F-actin networks,” Physical Review Letters 92 178101 (2004). [PUBMED]


    24. M.L. Gardel, M.T. Valentine , J.C. Crocker, A.R. Bausch, and D.A. Weitz. “Microrheology of entangled F-actin solutions,” Physical Review Letters 91 158302 (2003).[PUBMED]


    25. Vernita D. Gordon, M.T. Valentine , M.L. Gardel, Daniel Andor, Samantha Dennison, Alexei A. Bogdanov, D.A. Weitz, and Thomas S. Deisboeck. “Measuring the mechanical stress induced by a dynamically expanding multicellular tumor system within a three-dimensional in vitro assay,” Experimental Cell Research 289 58 (2003). [PUBMED]


    26. A.K. Popp, M.T. Valentine , P.D. Kaplan, D.A. Weitz. “Microscopic origin of light scattering in tissue,” Applied Optics 42 2871 (2003). [PUBMED]


    27. M.T. Valentine , A.K. Popp, P.D. Kaplan, and D.A. Weitz. “Microscope-based static light scattering instrument,” Optics Letters 26 890 (2001). [PUBMED]


    28. M.T. Valentine , P.D. Kaplan, D. Thota, J.C. Crocker, T. Gisler, R.K. Prud’homme, M. Beck, and D.A. Weitz. “Investigating the microenvironments of inhomogeneous soft materials with multiple particle tracking,” Physical Review E 64 061506 (2001).[PUBMED]


    29. M.T. Valentine , A.K. Popp, P.D. Kaplan, and D.A. Weitz “Microscope-based static light scattering instrument enables precise measurements of heterogeneous materials,” Optics and Photonics News 12 37 (2001). [PDF]
      [Edition highlights 200 of the most exciting new optics innovations of the year.]


    30. A.K. Popp, M.T. Valentine , P.D. Kaplan, and D.A. Weitz. “Light scattering microscope as a tool to investigate scattering heterogeneity in tissue,” Proceedings of the SPIE, Optical Biopsy III Conference, San Jose, CA, Robert R. Alfano, Ed. 3917 22 (2000). [PDF]


    31. John C. Crocker, M.T. Valentine , Eric R. Weeks, T. Gisler, P.D. Kaplan, A.G. Yodh, and D.A. Weitz. “Two-point microrheology of inhomogeneous soft materials,” Physical Review Letters 85 888 (2000). [PUBMED]


    32. M.T. Valentine , L.E. Dewalt, and H.D. Ou-Yang. “Forces on a colloidal particle in a polymer solution: a study using optical tweezers,” Journal of Physics: Condensed Matter (U.K.). 8 9477 (1996). [PDF]

    33. * indicates equal contribution














      Valentine Laboratory, California NanoSystems Institute, Room 2404, Elings Hall, University of California, Santa Barbara, CA 93106; 805-893-2594.