The Valentine Lab at the University of California, Santa Barbara
Molecular & Cellular Biomechanics, Biomaterials, Bioadhesion

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    1. Benjamin J. Lopez and Megan T. Valentine. "Mechanical effects of EB1 on microtubules depend on GTP hydrolysis state and presence of paclitaxel" Cytoskeleton 71 530-541 (2014).[LINK]


    2. Dezhi Yu, Nichole E. LaPointe, Elmer Guzman, Veronica Pessino, Leslie Wilson, Stuart C. Feinstein, and Megan T. Valentine. "Tau Proteins Harboring Neurodegeneration-linked Mutations Impair Kinesin Translocation in vitro" Journal of Alzheimer's Disease 39 301-314 (2014). [LINK]


    3. Yali Yang and Megan T. Valentine. “Determining the structure-mechanics relationships of dense microtubule networks with microscopy and microrheology,” Methods in Cell Biology 115 75-96 (2013). [LINK].


    4. Dezhi Yu, Veronica Pessino, Steve Kuei, and Megan T. Valentine. “Mechanical and functional properties of epothilone-stabilized microtubules,” Cytoskeleton 70(2) 74-84 (2013). [LINK].


    5. Bugra Kaytanli and Megan T. Valentine. “Evolute-based Hough transform method for characterization of ellipsoids,” Journal of Microscopy 249(3) 159-164 (2013). [LINK].


    6. Yali Yang, Mo Bai, William S. Klug, Alex J. Levine and Megan T. Valentine. “Microrheology of highly crosslinked microtubule networks is dominated by force-induced crosslinker unbinding,” Soft Matter 9 383-393 (2013). [LINK]


    7. David Valdman, Benjamin J. Lopez, Megan T. Valentine, and Paul J. Atzberger. “Force spectroscopy of complex biopolymers with heterogeneous elasticity,” Soft Matter 9 772-778 (2013). [LINK]


    8. Jun Lin and Megan T. Valentine. “High-force NdFeB-based magnetic tweezers device optimized for microrheology experiments,” Review of Scientific Instruments 83 053905 (2012). [LINK]


    9. Jun Lin and Megan T. Valentine. “Ring-shaped NdFeB-based magnetic tweezers enables oscillatory microrheology measurements,” Applied Physics Letters 100 201902 (2012). [LINK]


    10. David Valdman, Paul J. Atzberger, Dezhi Yu, Steve Kuei and Megan T. Valentine. “Spectral Analysis Methods for the Robust Measurement of the Flexural Rigidity of Biopolymers,” Biophysical Journal 102(5) 1144-1153 (2012). [LINK]


    11. Yali Yang*, Jun Lin*, Bugra Kaytanli, Omar Saleh and Megan T. Valentine. “Direct correlation between creep compliance and deformation in entangled and sparsely crosslinked microtubule networks,” Soft Matter 8 1776-1784 (2012). [LINK]


    12. Yali Yang*, Jun Lin*, Ryan Meschewski, Erin Watson, and Megan T. Valentine. “Portable magnetic tweezers device enables visualization of the three-dimensional microscale deformation of soft biological materials,” BioTechniques 51 29-34 (2011). [PDF]


    13. Megan T. Valentine and Steven M. Block. “Force and premature binding of ADP can regulate the processivity of individual Eg5 dimers,” Biophysical Journal 97 1671-7 (2009). [PUBMED]


    14. Michael T. Woodside and Megan T. Valentine . (2009) “Single-molecule manipulation using optical traps,” in Handbook of Single-Molecule Biophysics, eds. Peter Hinterdorfer and Antoine Van Oijen. New York, NY: Springer.


    15. Megan T. Valentine* , Nicholas R. Guydosh*, Braulio Gutiérrez-Medina*, Adrian N. Fehr*, Johan O. Andreasson*, and Steven M. Block. “Precision steering of an optical trap by electro-optic deflection,” Optics Letters 33 599-601 (2008). [PUBMED]


    16. Megan T. Valentine and Susan P. Gilbert. “To Step or Not to Step? How Biochemistry and Mechanics Influence Processivity in Kinesin and Eg5,” Current Opinion in Cell Biology 19 75-81 (2007). [PUBMED]


    17. Polly M. Fordyce*, Megan T. Valentine * and Steven M. Block. 2007. “Advances in surface-based assays for single molecules,” in Single-Molecule Techniques: A Laboratory Manual, eds. Paul Selvin and Taekjip Ha. Woodbury, NY: Cold Spring Harbor Laboratory Press.


    18. Megan T. Valentine , Polly M. Fordyce, and Steven M. Block. “Eg5 steps it up!,” Cell Division 1 31 (2006). [PUBMED]


    19. Megan T. Valentine *, Polly M. Fordyce*, Troy C. Krzysiak, Susan P. Gilbert, Steven M. Block. “Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro,” Nature Cell Biology 8 470 (2006). [PUBMED]


    20. M.T. Valentine , Z.E. Perlman, T.J. Mitchison, and D.A. Weitz. “Mechanical properties of Xenopus egg cytoplasmic extracts,” Biophysical Journal 88 680 (2005). [PUBMED]


    21. M.L. Gardel, M.T. Valentine , and D.A. Weitz. (2005) “Microrheology” in Microscale Diagnostic Techniques ed. K. Breuer. New York: Springer-Verlag. [PDF]


    22. M.T. Valentine , Z.E. Perlman, M.L. Gardel, J.H. Shin, P. Matsudaira, T.J. Mitchison, and D.A. Weitz. “Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials,” Biophysical Journal 86 4004-14 (2004). [PUBMED]


    23. I.Y. Wong, M.L. Gardel, David R. Reichman, Eric R. Weeks, M.T. Valentine , A.R. Bausch, D.A. Weitz. “Anomalous diffusion probes microstructure dynamics of entangled F-actin networks,” Physical Review Letters 92 178101 (2004). [PUBMED]


    24. M.L. Gardel, M.T. Valentine , J.C. Crocker, A.R. Bausch, and D.A. Weitz. “Microrheology of entangled F-actin solutions,” Physical Review Letters 91 158302 (2003).[PUBMED]


    25. Vernita D. Gordon, M.T. Valentine , M.L. Gardel, Daniel Andor, Samantha Dennison, Alexei A. Bogdanov, D.A. Weitz, and Thomas S. Deisboeck. “Measuring the mechanical stress induced by a dynamically expanding multicellular tumor system within a three-dimensional in vitro assay,” Experimental Cell Research 289 58 (2003). [PUBMED]


    26. A.K. Popp, M.T. Valentine , P.D. Kaplan, D.A. Weitz. “Microscopic origin of light scattering in tissue,” Applied Optics 42 2871 (2003). [PUBMED]


    27. M.T. Valentine , A.K. Popp, P.D. Kaplan, and D.A. Weitz. “Microscope-based static light scattering instrument,” Optics Letters 26 890 (2001). [PUBMED]


    28. M.T. Valentine , P.D. Kaplan, D. Thota, J.C. Crocker, T. Gisler, R.K. Prud’homme, M. Beck, and D.A. Weitz. “Investigating the microenvironments of inhomogeneous soft materials with multiple particle tracking,” Physical Review E 64 061506 (2001).[PUBMED]


    29. M.T. Valentine , A.K. Popp, P.D. Kaplan, and D.A. Weitz “Microscope-based static light scattering instrument enables precise measurements of heterogeneous materials,” Optics and Photonics News 12 37 (2001). [PDF]
      [Edition highlights 200 of the most exciting new optics innovations of the year.]


    30. A.K. Popp, M.T. Valentine , P.D. Kaplan, and D.A. Weitz. “Light scattering microscope as a tool to investigate scattering heterogeneity in tissue,” Proceedings of the SPIE, Optical Biopsy III Conference, San Jose, CA, Robert R. Alfano, Ed. 3917 22 (2000). [PDF]


    31. John C. Crocker, M.T. Valentine , Eric R. Weeks, T. Gisler, P.D. Kaplan, A.G. Yodh, and D.A. Weitz. “Two-point microrheology of inhomogeneous soft materials,” Physical Review Letters 85 888 (2000). [PUBMED]


    32. M.T. Valentine , L.E. Dewalt, and H.D. Ou-Yang. “Forces on a colloidal particle in a polymer solution: a study using optical tweezers,” Journal of Physics: Condensed Matter (U.K.). 8 9477 (1996). [PDF]

    33. * indicates equal contribution














      Valentine Laboratory, California NanoSystems Institute, Room 2404, Elings Hall, University of California, Santa Barbara, CA 93106; 805-893-2594.